锦灯笼

中文文本参考：《中国药典（2020年版）》
English text reference: Chinese Pharmacopoeia (2020 Edition)

概述 Overview

本品为茄科植物酸浆Physalis alkekengi L. var. franchetii (Mast.) Makino的干燥宿萼或带果实的宿萼。秋季果实成熟、宿萼呈红色或橙红色时采收，干燥。
Physalis Calyx with Fruit is the dried calyx or calyx with fruit of Physalis alkekengi L. var. franchetii (Mast.) Makino (Fam. Solanaceae). The drug is collected in autumn when the fruit is ripe and the calyx is red or orange-red, removed from the fruit, and dried.

性状 Description

本品略呈灯笼状，多压扁，长3～4.5cm，宽2.5～4cm。表面橙红色或橙黄色，有5条明显的纵棱，棱间有网状的细脉纹。顶端渐尖，微5裂，基部略平截，中心凹陷有果梗。体轻，质柔韧，中空，或内有棕红色或橙红色果实。果实球形，多压扁，直径1～l.5cm，果皮皱缩，内含种子多数。气微，宿萼味苦，果实味甘、微酸。
Calyx slightly lantern-shaped, often flattened, 3-4.5 cm long, 2.5-4 cm wide; surface orange-red or orange-yellow, with 5 distinct longitudinal ridges, the ridges with a reticulate venation. Apex acuminate, slightly 5-lobed, base slightly truncate, centre concave with a fruit stalk. Light in weight, texture flexible and tough, hollow or with brownish-red or orange-red fruit. Fruit spherical, often flattened, 1-1.5 cm in diameter; pericarp wrinkled, containing numerous seeds. Odour, slight; taste of calyx, bitter; taste of fruit, sweet and slightly sour.

鉴别 Identification

（1）本品粉末橙红色。表皮毛众多。腺毛头部椭圆形，柄2～4细胞，长95～170μm。非腺毛3～4细胞，长130～170μm，胞腔内含橙红色颗粒状物。宿萼内表皮细胞垂周壁波状弯曲；宿萼外表皮细胞垂周壁平整，气孔不定式。薄壁组织中含多量橙红色颗粒。
(1) The powder is orange-red. Numerous hairs on the surface. Glandular hairs with elliptical heads, 2-4 cells in the stalk, 95-170 μm long. Non-glandular hairs 3-4 cells, 130-170 μm long, containing orange-red granules in the cell cavity. Epidermal cells of the calyx are bent in a wavy manner along the periclinal wall; epidermal cells of the outer surface of the calyx are flat along the periclinal wall, and the stomata are anomocytic. The parenchyma contains a large amount of orange-red granules.

（2）取本品粉末0.5g，加甲醇5ml，超声处理10分钟，滤过，取滤液作为供试品溶液。另取酸浆苦味素L对照品，加二氯甲烷制成每1ml含1mg的溶液，作为对照品溶液。照薄层色谱法（通则0502）试验，吸取供试品溶液15μl、对照品溶液2μl，分别点于同一高效硅胶G薄层板上，以三氯甲烷-丙酮-甲醇（25∶1∶1）为展开剂，展开，取出，晾干，喷以5%硫酸乙醇溶液，在105℃加热至斑点显色清晰，置紫外光灯（365nm）下检视。供试品色谱中，在与对照品色谱相应的位置上，显相同颜色的荧光斑点。
(2) Take 0.5g of the powder, add 5ml of methanol, sonicate for 10 minutes, filter, and take the filtrate as the test solution. Take Physalin L CRS as the reference substance, add dichloromethane to make a solution containing 1mg per ml as the reference solution. Perform the thin-layer chromatography test<0502>, take 15μl of the test solution and 2μl of the reference solution, spot them separately on the same high-performance silica gel G thin-layer plate, use a mixture of chloroform-acetone-methanol (25:1:1) as the mobile phase, develop, take out, dry, spray with a 5% solution of sulfuric acid in ethanol, heat at 105°C until the spots are clearly visible, and examine under ultraviolet light at 365 nm. The fluorescent spots in the chromatogram of the test solution are the same color and in the corresponding positions as those in the chromatogram of the reference solution.

检查 Examination

水分 Water

不得过10.0%（通则0832第二法）。
Not more than 10.0 per cent <0832,method 2>.

含量测定 Content determination

照高效液相色谱法（通则0512）测定。
Determine by high-performance liquid chromatography <0512>.

色谱条件与系统适用性试验 Chromatographic conditions and system suitability test

以十八烷基硅烷键合硅胶为填充剂；以乙腈-0.2%磷酸溶液（20∶80）为流动相；检测波长为350nm。理论板数按木犀草苷峰计算应不低于3000。
Use octadecylsilane bonded silica gel as the filler; use acetonitrile-0.2% phosphoric acid solution (20:80) as the mobile phase; detect at a wavelength of 350nm. The theoretical plate number calculated based on the peak of acteoside should not be less than 3000.

对照品溶液的制备 Preparation of reference solution

取木犀草苷对照品适量，精密称定，加甲醇制成每1ml含40μg的溶液，即得。
Take an appropriate amount of acteoside reference substance, accurately weigh, dissolve in methanol to obtain a solution containing 40μg per 1ml.

供试品溶液的制备 Preparation of test solution

取本品粉末（过三号筛）约0.4g，精密称定，置具塞锥形瓶中，精密加入70%甲醇20ml，密塞，称定重量，超声处理（功率250W，频率40kHz）1小时，放冷，再称定重量，用70%甲醇补足减失的重量，摇匀，滤过，取续滤液，即得。
Take about 0.4g of the powder of this product (passed through a No. 3 sieve), accurately weigh, place it in a stoppered conical flask, accurately add 20ml of 70% methanol, seal the flask, weigh, subject to ultrasonic treatment (power 250W, frequency 40kHz) for 1 hour, cool, weigh again, make up for the lost weight with 70% methanol, shake well, filter, and take the filtrate.

测定法 Determination method

分别精密吸取对照品溶液与供试品溶液各20μl，注入液相色谱仪，测定，即得。
Accurately take 20μl of the reference solution and the test solution, inject into the liquid chromatograph, determine, and obtain the result.

本品按干燥品计算，含木犀草苷（C21H20O11）不得少于0.10%。
Calculated on the dried product, the content of acteoside (C21H20O11) should not be less than 0.10%.

性 Property

寒。
Cold.

味 Flavor

苦。
Bitter.

归经 Meridian tropism

归肺经。
Lung meridian.

功能 Actions

清热解毒，利咽化痰，利尿通淋。
To clear heat and detoxify, benefit the throat and resolve phlegm, promote diuresis and relieve stranguria.

主治 Indications

用于咽痛音哑，痰热咳嗽，小便不利，热淋涩痛；外治天疱疮，湿疹。
Used for sore throat and hoarseness, cough with phlegm-heat, difficult urination, hot and painful urination; externally used for pemphigus and eczema.

用量 Dosage

5～9g。
5-9 g.

用法 Administration

外用适量，捣敷患处。
For external use, apply an appropriate amount to the affected area.

贮藏 Storage

置通风干燥处，防蛀。
Store in a well-ventilated and dry place, and protect against moth.

锦灯笼

文本参考：《中国药典（2015年版）》
Text reference: Chinese Pharmacopoeia (2015 Edition)

概述 Overview

本品为茄科植物酸浆Physalis alkekengi L. var. franchetii(Mast.)Makino的干燥宿萼或带果实的宿萼。秋季果实成熟、宿萼呈红色或橙红色时采收，干燥。
Franchet Groundcherry Fruit is the dried persistent calyx or the persistent calyx with fruit of Physalis alkekengi L. var. franchetii(Mast.)Makino (Fam.Solanaceae). The drug is collected in autumn when the fruit is ripe and the persistent calyx turns red or orange-red, and dried.

性状 Description

本品略呈灯笼状，多压扁，长3～4.5cm，宽2.5～4cm。表面橙红色或橙黄色，有5条明显的纵棱，棱间有网状的细脉纹。顶端渐尖，微5裂，基部略平截，中心凹陷有果梗。体轻，质柔韧，中空，或内有棕红色或橙红色果实。果实球形，多压扁，直径1～1.5cm，果皮皱缩，内含种子多数。气微，宿萼味苦，果实味甘、微酸。
Somewhat lantern-shaped, mostly compressed, 3-4.5 cm long, 2.5-4 cm wide. Externally orange-red or orange-yellow, possessing 5 distinct longitudinal ribs, with fine reticulate veins between them. Apex acuminate, slightly 5-lobed, base somewhat truncate, centre dented, with a fruit stalk. Texture light and pliable, hollowed, some containing brownish-red or orange-red fruit. Fruit spherical, mostly compressed, 1-1.5 cm in diameter, pericarp shrunken, containing numerous seeds. Odour, slight; taste, calyx bitter and fruit sweet, slightly sour.

鉴别 Identification

（1）本品粉末橙红色。表皮毛众多。腺毛头部椭圆形，柄2～4细胞，长95～170μm。非腺毛3～4细胞，长130～170μm，胞腔内含橙红色颗粒状物。宿萼内表皮细胞垂周壁波状弯曲；宿萼外表皮细胞垂周壁平整，气孔不定式。薄壁组织中含多量橙红色颗粒。
（2）取本品粉末0.5g，加甲醇5ml，超声处理10分钟，滤过，取滤液作为供试品溶液。另取酸浆苦味素L对照品，加二氯甲烷制成每1ml含1mg的溶液，作为对照品溶液。照薄层色谱法（通则0502）试验，吸取供试品溶液15μl、对照品溶液2μl，分别点于同一高效硅胶G薄层板上，以三氯甲烷-丙酮-甲醇（25：1：1）为展开剂，展开，取出，晾干，喷以5%硫酸乙醇溶液，在l05℃加热至斑点显色清晰，置紫外光灯（365mn）下检视。供试品色谱中，在与对照品色谱相应的位置上，显相同颜色的荧光斑点。

检查 Examination

水分 Water

不得过10.0%（通则0832第二法）。
Not more than 10.0 per cent <0832, method 2>.

含量测定 Assay

照高效液相色谱法（通则0512）测定。
Carry out the method for high performance liquid chromatography<0512>.

色谱条件与系统适用性试验 Chromatographic system and system suitability

以十八烷基硅烷键合硅胶为填充剂；以乙腈-0.2%磷酸溶液（20：80）为流动相；检测波长为350nm。理论板数按木犀草苷峰计算应不低于3000。
Use oetadecylsilane bonded silica gel as the stationary phase and a mixture of acetonitrile and 0.2% phosphoric acid solution (20 : 80) as the mobile phase. As detector a spectrophotometer set at 350 nm. The number of theoretical plates of the column is not less than 3000, calculated with the reference to the peak of luteolin.

对照品溶液的制备 Reference solution

取木犀草苷对照品适量，精密称定，加甲醇制成每1ml含40μg的溶液，即得。
Dissolve a quantity of luteolin CRS, accurately weighed, in methanol to produce a solution containing 40 μg per ml as the reference solution.

供试品溶液的制备 Test solution

取本品粉末（过三号筛）约0.4g，精密称定，置具塞锥形瓶中，精密加入70%甲醇20ml，密塞，称定重量，超声处理（功率250W，频率40kHZ）1小时，放冷，再称定重量，用70%甲醇补足减失的重量，摇匀，滤过，取续滤液，即得。
Weigh accurately 0.4 g of the powder (through No.3 sieve) in a conical flask with stopper, add 20 ml of 70% methanol, tightly stopper, weigh accurately and ultrasonicate(power 250 W, frequency 40 kHz) for 1 hour, cool and weigh again, make up the loss in weight with 70% methanol to the initial weight, mix well, filter. Use the successive filtrate as the test solution.

测定法 Procedure

分别精密吸取对照品溶液与供试品溶液各20μl，注入液相色谱仪，测定，即得。
Inject accurately 20 μl each of the reference solution and the test solution, into the column, and calculate the content.

本品按干燥品计算，含木犀草苷（C21H20O11）不得少于0.10%。
It contains not less than 0.10 per cent of luteolin (CHO), calculated with reference to the dried drug.

性味与归经 Property and Flavor

苦，寒。归肺经。
Cold; bitter. Lung meridian.

功能与主治 Actions and Indications

清热解毒，利咽化痰，利尿通淋。用于咽痛音哑，痰热咳嗽，小便不利，热淋涩痛；外治天疱疮，湿疹。
To clear heat, remove toxin, soothe the throat, resolve phlegm, promote unration urine and relieve stranguria. Sore throat, hoarseness, phlegm-heat cough, inhibited urination, and heat strangury with difficulty and pain; Topical application: pemphigus and eczema.

用法与用量 Administration and dosage

5～9g。外用适量，捣敷患处。
5-9 g. Appropriate amount for topical application, mashed for applying to pars affecta.

贮藏 Storage

置通风干燥处，防蛀。
Preserve in a ventilated and dry place, and protect from moth.