根据《中国药典·2020年版·一部》记载:本品为马鞭草科植物杜虹花Callicarpa formosana Rolfe的干燥叶。夏、秋二季枝叶茂盛时釆摘,干燥。
This product is the dried leaves of the plant Callicarpa formosana Rolfe, a species in the Verbenaceae family. The leaves are harvested during the summer and autumn when the branches and leaves are lush, and then dried.
NMM ID | nmm-01wj |
系统名 | Callicarpa pedunculata Leaf |
系统中文名 | 杜虹花叶(dù hóng huā yè) |
通用名 | Zi-zhu-ye |
通用中文名 | 紫珠叶(zǐ zhū yè) |
类型 | plant |
物种基源 | Callicarpa pedunculata | 杜虹花 |
药用部位 | leaf | 叶 |
特殊描述 | |
炮制方法 | |
系统名命名解释 | 根据《中国药典·2020年版·一部》记载:本品为马鞭草科植物杜虹花Callicarpa formosana Rolfe的干燥叶。夏、秋二季枝叶茂盛时釆摘,干燥。 |
通用名命名解释 | NMMGN衍生自《中国药典·2020年版·一部》相关中药材中文名。 |
上级药材 | |
下级药材 | |
创建人 | |
审核专家 |
紫珠叶
中文文本参考:《中国药典(2020年版)》
English text reference: Chinese Pharmacopoeia (2020 Edition)
概述 Overview
本品为马鞭草科植物杜虹花Callicarpa formosana Rolfe的干燥叶。夏、秋二季枝叶茂盛时采摘,干燥。
Callicarpa Leaf is the dried leaf of Callicarpa formosana Rolfe (Fam. Verbenaceae). The drug is collected in summer and autumn when the branches and leaves are luxuriant, removed from impurities, and dried.
性状 Description
本品多皱缩、卷曲,有的破碎。完整叶片展平后呈卵状椭圆形或椭圆形,长4~19cm,宽2.5~9cm。先端渐尖或钝圆,基部宽楔形或钝圆,边缘有细锯齿,近基部全缘。上表面灰绿色或棕绿色,被星状毛和短粗毛;下表面淡绿色或淡棕绿色,密被黄褐色星状毛和金黄色腺点,主脉和侧脉突出,小脉伸入齿端。叶柄长0.5~1.5cm。气微,味微苦涩。
Leaves crumpled and curled, some broken. When the intact leaf is flattened, it is ovate-elliptic or elliptic, 4-19cm long, 2.5-9cm wide. Apex gradually acute or obtuse-rounded, base broadly cuneate or obtuse-rounded, margin finely serrate, nearly entire near the base. Upper surface grayish-green or brownish-green, with stellate hairs and short coarse hairs; lower surface pale green or pale brownish-green, densely covered with yellow-brown stellate hairs and golden glandular dots, prominent midrib and lateral veins, minor veins extending to the teeth. Petiole 0.5-1.5cm long. Odour, slight; taste, slightly bitter and astringent.
鉴别 Identification
(1)本品粉末灰黄色至棕褐色。非腺毛有两种:一种为星状毛,大多碎断,木化,完整者1至数轮,每轮1~6侧生细胞;另一种非腺毛1~3细胞,直径25~33μm,壁较厚。腺鳞头部8~11细胞,扁球形,柄极短。小腺毛头部2~4细胞,柄1~2细胞。草酸钙簇晶细小,散布于叶肉细胞中。
(1)The powder is grayish-yellow to brownish-brown. There are two types of non-glandular hairs: one is stellate hairs, mostly broken and lignified, with 1 to several rounds of 1-6 lateral cells in each round; the other non-glandular hairs are 1-3 cells in diameter, with thicker walls. The head of glandular scale consists of 8-11 cells, flat and spherical, with a very short stalk. The head of small glandular hair consists of 2-4 cells, with a stalk of 1-2 cells. Calcium oxalate cluster crystals are small and scattered in the leaf parenchyma cells.
(2)取本品粉末1g,加乙醚30ml,加热回流30分钟,滤过,滤液蒸干,残渣加甲醇2ml使溶解,取上清液作为供试品溶液。另取熊果酸对照品,加甲醇制成每1ml含1mg的溶液,作为对照品溶液。照薄层色谱法(通则0502)试验,吸取供试品溶液3~5μl、对照品溶液3μl,分别点于同一硅胶G薄层板上,以环己烷-三氯甲烷-乙酸乙酯-冰醋酸(20∶5∶8∶0.1)为展开剂,展开,取出,晾干,喷以10%硫酸乙醇溶液,在105℃加热至斑点显色清晰。供试品色谱中,在与对照品色谱相应的位置上,显相同颜色的斑点。
(2)Take 1g of the powder, add 30ml of ether, heat under reflux for 30 minutes, filter, evaporate the filtrate to dryness, dissolve the residue in 2ml of methanol, and take the supernatant as the test solution. Take ursolic acid CRS, add methanol to make a solution containing 1mg per ml as the reference solution. Carry out the method for thin layer chromatography<0502>, using silica gel G as the coating substance and a mixture of cyclohexane, chloroform, ethyl acetate, and glacial acetic acid (20:5:8:0.1) as the mobile phase. Apply separately to the plate 3-5μl of the test solution and 3μl of the reference solution. After developing and removal of the plate, dry in air. Spray with a 10% solution of sulfuric acid in ethanol, heat at 105°C to the spots clear. The spot in the chromatogram obtained with the test solution corresponds in position and colour to the spot in the chromatogram obtained with the reference solution.
检查 Examination
水分 Water
不得过15.0%(通则0832第二法)。
Not more than 15.0 per cent <0832,method 2>.
总灰分 Total ash
不得过11.0%(通则2302)。
Not more than 11.0 per cent <2302>.
浸出物 Extractives
照醇溶性浸出物测定法(通则2201)项下的热浸法测定,用稀乙醇作溶剂,不得少于20.0%。
Carry out the method for determination of ethanol-soluble Extractives <2201,the hot maceration method>, using diluted ethanol as the solvent,not less than 20.0 per cent.
含量测定 Content determination
照高效液相色谱法(通则0512)测定。
Carry out the method for determination of content by high performance liquid chromatography <0512>.
色谱条件与系统适用性试验 Chromatographic conditions and system suitability test
以十八烷基硅烷键合硅胶为填充剂;以乙腈-0.5%磷酸溶液(17∶83)为流动相;检测波长为332nm。理论板数按毛蕊花糖苷峰计算应不低于3000。
Use octadecylsilane bonded silica gel as the filler; use acetonitrile-0.5% phosphoric acid solution (17:83) as the mobile phase; detect at a wavelength of 332nm. The theoretical plate number calculated based on the peak of astragalin should not be less than 3000.
对照品溶液的制备 Preparation of reference solution
取毛蕊花糖苷对照品适量,精密称定,加50%甲醇制成每1ml含50μg的溶液,即得。
Take an appropriate amount of astragalin reference substance, accurately weigh, add 50% methanol to make a solution containing 50μg per ml.
供试品溶液的制备 Preparation of test solution
取本品粉末(过四号筛)约0.25g,精密称定,置具塞锥形瓶中,精密加入50%甲醇50ml,密塞,称定重量,放置过夜,加热回流1小时,放冷,再称定重量,用50%甲醇补足减失的重量,摇匀,滤过,取续滤液,即得。
Take about 0.25g of the powder of this product (passed through a No. 4 sieve), accurately weigh, place it in a stoppered conical flask, accurately add 50% methanol 50ml, seal tightly, weigh, let it stand overnight, heat reflux for 1 hour, cool, weigh again, make up for the weight loss with 50% methanol, shake well, filter, and take the filtrate.
测定法 Determination method
分别精密吸取对照品溶液与供试品溶液各10μl,注入液相色谱仪,测定,即得。
Accurately take 10μl of the reference solution and the test solution, respectively, inject into the liquid chromatograph, and determine.
本品按干燥品计算,含毛蕊花糖苷(C29H36O15)不得少于0.50%。
Calculated on the dried product, the content of astragalin (C29H36O15) should not be less than 0.50%.
饮片 Prepared slices
炮制 Processing
除去杂质,洗净,切段,干燥。
Eliminate Foreign matter,wash, cut into sections, and dry in the sun.
性 Property
凉。
Cold.
味 Flavor
苦、涩。
Bitter and astringent.
归经 Meridian tropism
归肝、肺、胃经。
Liver, lung, and stomach meridians.
功能 Actions
凉血收敛止血,散瘀解毒消肿。
To cool the blood, astringe and stop bleeding, disperse stasis, detoxify, and reduce swelling.
主治 Indications
用于衄血,咯血,吐血,便血,崩漏,外伤出血,热毒疮疡,水火烫伤。
Used for bleeding, hemoptysis, vomiting blood, blood in the stool, metrorrhagia and metrostaxis, bleeding from external injuries, heat-toxin sores and ulcers, and scalds.
用量 Dosage
3~15g。外用适量。
3-15g. For external use, apply an appropriate amount.
用法 Administration
研末吞服1.5~3g。敷于患处。
Grind into powder and take orally 1.5-3g. Apply to the affected area.
贮藏 Storage
置通风干燥处。
Store in a well-ventilated and dry place.
紫珠叶
文本参考:《中国药典(2015年版)》
Text reference: Chinese Pharmacopoeia (2015 Edition)
概述 Overview
本品为马鞭草科植物杜虹花Callicarpa formosana Rolfe的干燥叶。夏、秋二季枝叶茂盛时采摘,干燥。
Callicarpa Formosana Leaf is the dried leaf of Callicarpa formosana Rolfe (Fam. Verbenaceae). The drug is collected in summer and autumn when foliage branch growing luxuriantly, and dried.
性状 Description
本品多皱缩、卷曲,有的破碎。完整叶片展平后呈卵状椭圆形或椭圆形,长4~19cm,宽2.5~9cm。先端渐尖或钝圆,基部宽楔形或钝圆,边缘有细锯齿,近基部全缘。上表面灰绿色或棕绿色,被星状毛和短粗毛;下表面淡绿色或淡棕绿色,密被黄褐色星状毛和金黄色腺点,主脉和侧脉突出,小脉伸入齿端。叶柄长0.5~1.5cm。气微,味微苦涩。
Mostly crumpled and rolled, some broken. When whole, ovate-elliptical or elliptical, 4-19 cm long, 2.5-9 cm wide. Apex acuminate or obtuse-rounded, base broadly cuneate or obtuse-rounded, margin serrulate, entire near the base. Upper surface greyish-green or brownish green, covered with stellate hairs and dumpy hairs; lower surface pale green or pale brownish-green, densely covered with yellowish brown stellate hairs and golden-yellow glandular dots, midrib and lateral veins prominent, veinlets extending to the end of serra. Petiols 0.5-1.5 cm long. Odour, slight; taste, slightly bitter and astringent.
鉴别 Identification
(1)本品粉末灰黄色至棕褐色。非腺毛有两种:一种为星状毛,大多碎断,木化,完整者1至数轮,每轮1~6侧生细胞;另一种非腺毛1~3细胞,直径25~33μm,壁较厚。腺鳞头部8~11细胞,扁球形,柄极短。小腺毛头部2~4细胞,柄1~2细胞。草酸钙簇晶细小,散布于叶肉细胞中。
(2)取本品粉末1g,加乙醚30ml,加热回流30分钟,滤过,滤液蒸干,残渣加甲醇2ml使溶解,取上清液作为供试品溶液。另取熊果酸对照品,加甲醇制成每1ml含1mg的溶液,作为对照品溶液。照薄层色谱法(通则0502)试验,吸取供试品溶液3~5μl、对照品溶液3μl,分别点于同一硅胶G薄层板上,以环己烷-三氯甲烷-乙酸乙酯-冰醋酸(20:5:8:0.1)为展开剂,展开,取出,晾干,喷以10%硫酸乙醇溶液,在105℃加热至斑点显色清晰。供试品色谱中,在与对照品色谱相应的位置上,显相同颜色的斑点。
检查 Examination
水分 Water
不得过15.0%(通则0832第二法)。
Not more than 15.0 per cent <0832, method 2>.
总灰分 Total ash
不得过11.0%(通则2302)。
Not more than 11.0 per cent <2302>.
浸出物 Extractives
照醇溶性浸出物测定法(通则2201)项下的热浸法测定,用稀乙醇作溶剂,不得少于20.0%。
Carry out the method for determination of ethanol-soluble extractives <2201, the hot extraction method>, using dilute ethanol as the solvent, not less than 20.0 per cent.
含量测定 Assay
照高效液相色谱法(通则0512)测定。
Carry out the method for high performance liquid chromatography <0512>.
色谱条件与系统适用性试验 Chromatographic system and system suitability
以十八烷基硅烷键合硅胶为填充剂;以乙腈-0.5%磷酸溶液(17:83)为流动相;检测波长为332nm。理论板数按毛蕊花糖苷峰计算应不低于3000。
Use octadecylsilane bonded silica gel as the stationary phase and a mixture of acetonitrile and 0.5% phosphoric acid (17:83) as the mobile phase. The detection wavelength is 332 nm. The theoretical plate number calculated with reference to the peak of verbascoside should not be less than 3000.
对照品溶液的制备 Preparation of reference solution
取毛蕊花糖苷对照品适量,精密称定,加50%甲醇制成每1ml含50μg的溶液,即得。
Dissolve a quantity of verbascoside CRS, accurately weighed, in 50% methanol to prepare a solution containing 50 μg per ml.
供试品溶液的制备 Preparation of test solution
取本品粉末(过四号筛)约0.25g,精密称定,置具塞锥形瓶中,精密加入50%甲醇50ml,密塞,称定重量,放置过夜,加热回流1小时,放冷,再称定重量,用50%甲醇补足减失的重量,摇匀,滤过,取续滤液,即得。
Weigh accurately 0.25 g of the powder (through No. 4 sieve) to a stoppered conical flask, add accurately 50 ml of 50% methanol, stopper tightly, weigh and allow to stand overnight. Heat under reflux for 1 hour, cool, weigh again, replenish the loss of the weight with 50% methanol, mix well and filter. Use the successive filtrate as the test solution.
测定法 Procedure
分别精密吸取对照品溶液与供试品溶液各10μl,注入液相色谱仪,测定,即得。
Inject accurately 10 μl of each of the reference solution and the test solution, respectively, into the column, and calculate the content.
本品按干燥品计算,含毛蕊花糖苷(C29H36O15)不得少于0.50%。
It contains not less than 0.50 per cent of verbascoside (C29H36O15), calculated with reference to the dried drug.
饮片 Prepared slices
紫珠叶 Callicarpa Formosana Leaf
炮制 Processing
除去杂质,洗净,切段,干燥。
Eliminate foreign matter, wash clean, cut into sections, and dry.
性 Property
凉。
Cool.
味 Flavor
苦、涩。
Bitter, astringent.
归经 Meridian tropism
归肝、肺、胃经。
Liver, lung, and stomach meridians.
功能 Actions
凉血收敛止血,散瘀解毒消肿。
To cool the blood, astringe and stanch bleeding, dissipate stasis, remove toxin, and relieve swelling.
主治 Indications
用于衄血,咯血,吐血,便血,崩漏,外伤出血,热毒疮疡,水火烫伤。
Epistaxis, hemoptysis, hematemesis, bloody stool, menstrual flooding and spotting, traumatic bleeding, sore and ulcer caused by heat toxin, scald and burn.
用量 Dosage
3~15g;研末吞服1.5~3g。外用适量,敷于患处。
3-15 g. Ground into powder for oral administration: 1.5-3 g. Appropriate amount for topical application.
贮藏 Storage
置通风干燥处。
Preserve in a ventilated and dry place.
本天然药材为马鞭草科植物杜虹花Callicarpa formosana Rolfe的干燥叶。夏、秋二季枝叶茂盛时釆摘,干燥。
This product is the dried leaves of the plant Callicarpa formosana Rolfe, a species in the Verbenaceae family. The leaves are harvested during the summer and autumn when the branches and leaves are lush, and then dried.