二色补血草，中药名。为白花丹科植物二色补血草Limoniumbicolor（Bunge）O.Ktunze的根或全草。具有益气血，散瘀止血的功效。主治病后体弱，胃脘痛，消化不良，妇女月经不调，崩漏，带下，尿血，痔血。
Er-se-bu-xue-cao, name of Chinese Medicinal Material. Limoniumbicolor) is the root or whole plant of the white-flowered plant Limoniumbicolor (Bunge) O.Ktunze. It has the functions of nourishing qi and blood, promoting blood circulation, and stopping bleeding. It is mainly used to treat post-illness weakness, epigastric pain, indigestion, irregular menstruation, menorrhagia, leukorrhea, hematuria, and hemorrhoids.

功效作用 Efficacy and Functions

益气血，散瘀止血。
Tonify qi and blood, promote blood circulation to remove blood stasis.

主治 Indications

病后体弱，胃脘痛，消化不良，妇女月经不调，崩漏，带下，尿血，痔血。
Post-illness weakness, epigastric pain, indigestion, irregular menstruation in women, menorrhagia, leukorrhea, hematuria, and hemorrhoids.

用法用量 Dosage and Administration

内服：煎汤，15-30g。
Internal administration: Decoction, 15-30g.

药理作用 Pharmacological Effects

止血作用：二色补血草水煎剂15g（生药）/kg、乙醇提取液15g（生药）/kg灌胃，均使大鼠出血时间明显缩短，对凝血时间无明显影响。二色补血草醇提液20g（生药）/kg灌胃，对大鼠实验性动脉血栓形成有明显促进作用，提示止血作用可能与其促进血小板粘附和聚集作用有关。乙醇提取物3g（生药）/kg、10g（生药）/kg灌胃，均使家兔循环血小板聚集率明显增加，但对凝血时间、凝血酶原时间、血浆复钙时间及纤维蛋白溶解时间、血小板计数、毛细血管通透性均无明显影响。乙醇提取物及水煎剂，均使离体兔耳血管灌注量明显减少。
Hemostatic effect: A water decoction of 15g/kg of the herb "Erse Bu Xue Cao" and an ethanol extract of 15g/kg (both in raw herb form) administered by gastric lavage significantly shortened the bleeding time in rats, with no significant effect on clotting time. Gastric lavage with a 20g/kg ethanol extract of "Erse Bu Xue Cao" (in raw herb form) showed a significant promoting effect on experimental arterial thrombosis formation in rats, suggesting that the hemostatic effect may be related to its promotion of platelet adhesion and aggregation. Gastric lavage with 3g/kg and 10g/kg of ethanol extract (in raw herb form) both significantly increased the platelet aggregation rate in rabbits, but had no significant effect on clotting time, prothrombin time, plasma recalcification time, fibrinogen dissolution time, platelet count, or capillary permeability. Both the ethanol extract and water decoction significantly reduced the perfusion volume in isolated rabbit ear blood vessels.

毒理作用 Toxic Effects

二色补血草煎剂给小鼠1次灌服的LD50为58.37±10.77g（生药）/kg。给予较大剂量后，小鼠活动降低，呼吸、心跳变快，有时大便变稀，小鼠死前多会全身抽搐。中毒死亡多发生在给药后2h内。
The LD50 of the decoction of Erse Bu Xue Cao given to mice by gavage is 58.37±10.77g (crude drug)/kg. After administration of a large dose, the activity of the mice decreases, respiration and heart rate increase, sometimes the feces become loose, and the mice often have convulsions throughout the body before death. Poisoning deaths mostly occur within 2 hours after administration.

相关论述 Relevant Discussion

1、《甘肃中草药手册》：“补血益气，活血调经。治病后体弱，消化不良，月经不调。”

1. "Gansu Herbal Manual": "Tonify blood and qi, activate blood circulation and regulate menstruation. Used for post-illness weakness, poor digestion, and irregular menstruation."

2、《北方常用中草药手册》：“止血散瘀。治子宫功能性出血，宫颈癌及其他出血。”
2. "Commonly Used Northern Herbal Manual": "Stop bleeding and disperse stasis. Used for functional uterine bleeding, cervical cancer, and other bleeding conditions."

3、《陕甘宁青中草药选》：“治肾盂肾炎，尿血。”
3. "Herbal Selections from Shaanxi, Gansu, Ningxia, and Qinghai": "Used for treating pyelonephritis and hematuria."

4、《内蒙古中草药》：“根：补气益血，滋养强壮。主治诸虚体弱，食欲不振。叶：温中健胃。主治胃溃疡，胃痛，胃癌。花枝：止血散瘀。主治功能性子宫出血，宫颈癌及其他出血。”
4. "Herbal Medicine from Inner Mongolia": "Root: Tonify qi and nourish blood, strengthening the body. Used for various deficiencies, weakness, and poor appetite. Leaf: Warm the middle and strengthen the stomach. Used for gastric ulcers, stomach pain, and stomach cancer. Flower and stem: Stop bleeding and disperse stasis. Used for functional uterine bleeding, cervical cancer, and other bleeding conditions."

5、《山西中草药》：“治宫颈癌伴发出血。”
5. "Shanxi Herbal Medicine": "Used for treating cervical cancer with accompanying bleeding."

临床应用 Clinical Applications

1、治子宫功能性出血，宫颈癌，肾盂肾炎，尿血：二色补血草15-60g。水煎服。（《陕甘宁青中草药选》）

1. To treat functional uterine bleeding, cervical cancer, pyelonephritis, and hematuria: 15-60g of Erse Bu Xue Cao. Decoction for oral administration. (Selected Herbal Medicines of Shaanxi, Gansu, Ningxia, and Qinghai)

2、治子宫功能性出血：补血草30g，水煎服；或制成50%注射液，每次2ml，肌内注射。（《宁夏中草药手册》）
2. To treat functional uterine bleeding: 30g of Bu Xue Cao. Decoction for oral administration; or prepare as a 50% injection, 2ml per dose, intramuscular injection. (Ningxia Herbal Manual)

3、治功能性子宫出血，宫颈癌伴发出血：矶松15g，仙鹤草15g。水煎服。（《山西中草药》）
3. To treat functional uterine bleeding and cervical cancer with bleeding: 15g of Ji Song, 15g of Xian He Cao. Decoction for oral administration. (Shanxi Herbal Medicine)

4、治月经不调：二色补血草30g。水煎服。
4. To treat menstrual irregularities: 30g of Erse Bu Xue Cao. Decoction for oral administration.

5、治胃癌：二色补血草、薏苡仁、菱角各30g。水煎服。（4-5方出自《内蒙古中草药》）
5. To treat gastric cancer: 30g each of Erse Bu Xue Cao, Yi Yi Ren, and Ling Jiao. Decoction for oral administration. (The above prescriptions are from Inner Mongolia Herbal Medicine)

加工炮制 Processing and Preparation

采收加工：春、秋、冬季采挖，洗净，晒干。
Harvest, dig, wash, and dry the herbs in spring, autumn, and winter.

药材鉴别 Herbal Identification

药材性状：根圆柱形，棕褐色。茎丛生，细圆柱形，呈“之”字形弯曲，长30-60cm，光滑无毛，断面中空。叶多脱落，基生叶匙形或长倒卵形，长约20cm，宽1-4cm，近于全缘，基部渐窄成翅状。外苞片长圆状宽卵形，边缘狭膜质，第一内苞片与外苞片相似，边缘宽膜质。花萼漏斗状，沿脉密生细硬毛，萼檐紫色、粉红色或白色，花冠黄色。气微，味微苦。
Morphological characteristics: Cylindrical roots, brownish. Stems clustered, slender cylindrical, zigzag-shaped, 30-60cm long, smooth and hairless, with hollow cross-section. Many leaves shed, basal leaves spoon-shaped or long ovate, about 20cm long, 1-4cm wide, nearly entire margin, gradually narrowing into winged base. Outer bracts elongated ovate, with narrow membranous edges, first inner bract similar to outer bract, with wide membranous edges. Calyx funnel-shaped, densely covered with fine stiff hairs along veins, calyx rim purple, pink, or white, corolla yellow. Slightly fragrant, slightly bitter taste.

植物学信息 Botanical Information

植物种属：白花丹科补血草属二色补血草。
The two-colored blood-tonifying herb (Erse Bu Xue Cao) is a plant of the Plumbaginaceae family, genus Limonium.

形态特征 Morphological Characteristics

多年生草本，高30-60cm。全株光滑无毛。根圆柱状，棕褐色。茎丛生，直立或倾斜。叶多基生，莲座状，叶片匙形或长倒卵形，长约20cm，宽1-4cm，近于全缘，基部渐窄成扁平的柄。花序圆锥状；花葶丛生，直立或斜生，通常有3-4棱角有时具沟槽，上部有分枝；花着生枝端，密集，略偏于一侧近头状的聚伞花序；萼筒漏斗状，棱上有毛，缘部5裂，折叠，干膜质，初时淡紫红或粉红色，而后变为白色，花后宿存；花瓣5，匙形至椭圆形，黄色；雄蕊5，着生于花瓣基部；子房长圆形，花柱5，分离，柱头头状。蒴果具5棱。花、果期7-10月。
Perennial herb, 30-60cm tall. The entire plant is smooth and hairless. The root is cylindrical and brownish. The stems are tufted, erect or inclined. The leaves are mostly basal, lotus-shaped, with spatulate or oblong-ovate leaf blades, about 20cm long and 1-4cm wide, nearly entire, gradually narrowing at the base into a flat petiole. The inflorescence is conical; the flower stalks are tufted, erect or oblique, usually with 3-4 edges and sometimes grooves, branching at the upper part; the flowers are densely clustered at the branch tips, slightly biased to one side, forming an umbel-like inflorescence; the calyx tube is funnel-shaped, hairy on the edges, 5-lobed at the margin, folded, membranous, initially pale purple-red or pink, then turning white, persistent after flowering; the petals are 5, spoon-shaped to elliptic, yellow; the stamens are 5, attached at the base of the petals; the ovary is oblong, with 5 separate styles, and the stigma is head-shaped. The capsule has 5 edges. Flowering and fruiting period is from July to October.

分布区域 Distribution Area

分布于辽宁、内蒙古、河北、山西、陕西、宁夏、甘肃、新疆、山东、江苏、河南等地。
Distributed in Liaoning, Inner Mongolia, Hebei, Shanxi, Shaanxi, Ningxia, Gansu, Xinjiang, Shandong, Jiangsu, Henan and other regions.

道地产区 Authentic Production Areas

产于辽宁、陕西、甘肃、山东、山西、河南、河北、江苏、内蒙古等地。自产自销。
It is produced in Liaoning, Shaanxi, Gansu, Shandong, Shanxi, Henan, Hebei, Jiangsu, Inner Mongolia, and other regions. It is self-produced and self-sold.

生长环境 Growing Environment

生于平原、丘陵和海滨的盐碱地或沙地。
Born in saline-alkali land or sandy land in plains, hills, and coastal areas.