阿胶

中文文本参考：《中国药典（2020年版）》
English text reference: Chinese Pharmacopoeia (2020 Edition)

概述 Overview

本品为马科动物驴Equus asinus L.的干燥皮或鲜皮经煎煮、浓缩制成的固体胶。
Donkey-hide Gelatin is the solid gelatin prepared by decocting and concentrating the dried skin or fresh skin of the donkey, an animal of the Equidae family.

制法 Preparation

将驴皮浸泡去毛，切块洗净，分次水煎，滤过，合并滤液，浓缩（可分别加入适量的黄酒、冰糖及豆油）至稠膏状，冷凝，切块，晾干，即得。
The donkey skin is soaked to remove the hair, cut into pieces and washed. It is decocted in water in several portions, filtered, and the filtrate is combined. The combined filtrate is concentrated (with the addition of appropriate amounts of yellow rice wine, rock sugar, and soybean oil) to obtain a thick paste. The paste is cooled, cut into pieces, and dried to obtain the final product.

性状 Description

本品呈长方形块、方形块或丁状。棕色至黑褐色，有光泽。质硬而脆，断面光亮，碎片对光照视呈棕色半透明状。气微，味微甘。
Donkey-hide Gelatin is in the form of rectangular blocks, square blocks, or pieces. It is brown to dark brown in color and has a glossy appearance. The texture is hard and brittle, and the fractured surface is shiny. When the fragments are held up to the light, they appear brown and translucent. It has a slight odor and a slightly sweet taste.

鉴别 Identification

取本品粉末0.1g，加1%碳酸氢铵溶液50ml，超声处理30分钟，用微孔滤膜滤过，取续滤液100μl，置微量进样瓶中，加胰蛋白酶溶液10μl（取序列分析用胰蛋白酶，加1%碳酸氢铵溶液制成每1ml中含1mg的溶液，临用时配制），摇匀，37℃恒温酶解12小时，作为供试品溶液。另取阿胶对照药材0.1g，同法制成对照药材溶液。照〔含量测定〕特征多肽项下色谱、质谱条件试验，选择质荷比（m/z）539.8（双电荷）→612.4和m/z539.8（双电荷）→923.8作为检测离子对。取阿胶对照药材溶液，进样5μl，按上述检测离子对测定的MRM色谱峰的信噪比均应大于3:1。吸取供试品溶液5μl，注入高效液相色谱-质谱联用仪，测定。以质荷比（m/z）539.8（双电荷）→612.4和m/z539.8（双电荷）→923.8离子对提取的供试品离子流色谱中，应同时呈现与对照药材色谱保留时间一致的色谱峰。
Take 0.1g of the powder, add 50ml of 1% ammonium bicarbonate solution, and sonicate for 30 minutes. Filter the solution through a microporous membrane, take 100μl of the filtrate, and place it in a microsampling bottle. Add 10μl of trypsin solution (prepare a solution containing 1mg of trypsin per ml of 1% ammonium bicarbonate solution for sequence analysis, and prepare it before use). Shake well and incubate at 37°C for 12 hours to obtain the test solution. Take 0.1g of the reference drug Ejiao, and prepare a solution using the same method as the test solution. Perform the test according to the chromatographic and mass spectrometric conditions under the characteristic peptide item in the determination of content. Select the mass-to-charge ratios (m/z) 539.8 (double charge)→612.4 and m/z 539.8 (double charge)→923.8 as the detection ion pairs. Take 5μl of the Ejiao reference drug solution and inject it into the high-performance liquid chromatography-mass spectrometry instrument for analysis. In the ion flo w chromatogram extracted with the ion pairs of m/z 539.8 (double charge)→612.4 and m/z 539.8 (double charge)→923.8, a chromatographic peak with the same retention time as the reference drug should be present.

检查 Examination

水分 Water

取本品1g，精密称定，加水2ml，加热溶解后，置水浴上蒸干，使厚度不超过2mm，照水分测定法（通则0832第二法）测定，不得过15.0%。
Take 1g of the sample, accurately weigh, add 2ml of water, dissolve by heating, evaporate on a water bath until the thickness does not exceed 2mm, and determine according to the method for water determination <0832, method 2>, not more than 15.0 per cent.

重金属及有害元素 Heavy metals and harmful elements

照铅、镉、砷、汞、铜测定法（通则2321原子吸收分光光度法或电感耦合等离子体质谱法）测定，铅不得过5mg/kg；镉不得过0.3mg/kg；砷不得过2mg/kg，汞不得过0.2mg/kg，铜不得过20mg/kg。
Determine according to the method for determination of lead, cadmium, arsenic, mercury, and copper <2321, atomic absorption spectrophotometry or inductively coupled plasma mass spectrometry>. The lead content should not exceed 5mg/kg; the cadmium content should not exceed 0.3mg/kg; the arsenic content should not exceed 2mg/kg; the mercury content should not exceed 0.2mg/kg; and the copper content should not exceed 20mg/kg.

水不溶物 Insoluble matter

取本品1.0g，精密称定，加水5ml，加热使溶解，转移至已恒重10ml具塞离心管中，用温水5ml分3次洗涤，洗液并入离心管中，摇匀。置40℃水浴保温15分钟，离心（转速为每分钟2000转）10分钟，去除管壁浮油，倾去上清液，沿管壁加入温水至刻度，离心，如法清洗3次，倾去上清液，离心管在105℃加热2小时，取出，置干燥器中冷却30分钟，精密称定，计算，即得。
Take 1.0g of the sample, accurately weigh, add 5ml of water, heat to dissolve, transfer to a centrifuge tube with a constant weight of 10ml, wash with 5ml of warm water in 3 portions, combine the washings into the centrifuge tube, shake well. Keep warm in a 40°C water bath for 15 minutes, centrifuge (at a speed of 2000 rpm) for 10 minutes, remove the floating oil on the tube wall, pour off the supernatant along the tube wall, add warm water to the mark along the tube wall, centrifuge, repeat the washing process 3 times, pour off the supernatant, heat the centrifuge tube at 105°C for 2 hours, take out, cool in a desiccator for 30 minutes, accurately weigh, calculate, and obtain the result.

本品水不溶物不得过2.0%。
The water insoluble substance of this product shall not exceed 2.0%.

其他 IOther

应符合胶剂项下有关的各项规定（通则0184）。
The relevant provisions under Adhesives <0184> shall be complied with.

含量测定 Assay

氨基酸 Amino acids

照高效液相色谱法（通则0512）测定。
Carry out the method for high performance liquid chromatography <0512>.

色谱条件与系统适用性试验 Chromatographic conditions and system suitability test

以十八烷基硅烷键合硅胶为填充剂；以乙腈-0.1mol/L醋酸钠溶液（用醋酸调节pH值至6.5）（7:93）为流动相A，以乙腈-水（4:1）为流动相B，按下表中的规定进行梯度洗脱；检测波长为254nm；柱温为43℃。理论板数按L-羟脯氨酸峰计算应不低于4000。
Octadecylsilane-bonded silica gel was used as filler; acetonitrile-0.1 mol/L sodium acetate solution (pH adjusted to 6.5 with acetic acid) (7:93) was used as the mobile phase A, and acetonitrile-water (4:1) was used as the mobile phase B. The gradient elution was performed according to the following table; the detection wavelength was 254 nm; and the column temperature was 43 ℃. The theoretical plate count should be not less than 4000 based on the L-hydroxyproline peak.

对照品溶液的制备 Preparation of reference solution

取L-羟脯氨酸对照品、甘氨酸对照品、丙氨酸对照品、L-脯氨酸对照品适量，精密称定，加0.1mol/L盐酸溶液制成每1ml分别含L-羟脯氨酸80μg、甘氨酸0.16mg、丙氨酸70μg、L-脯氨酸0.12mg的混合溶液，即得。
Take the appropriate amount of L-hydroxyproline control, glycine control, alanine control, L-proline control, weigh it precisely, add 0.1 mol/L hydrochloric acid solution to make a mixed solution containing 80 μg of L-hydroxyproline, 0.16 mg of glycine, 70 μg of alanine, 0.12 mg of L-proline per 1 ml, that is to say.

供试品溶液的制备 Preparation of test solution

取本品粗粉约0.25g，精密称定，置25ml量瓶中，加0.1mol/L盐酸溶液20ml，超声处理（功率500W，频率40kHz）30分钟，放冷，加0.1mol/L盐酸溶液至刻度，摇匀。精密量取2ml，置5ml安瓿中，加盐酸2ml，150℃水解1小时，放冷，移至蒸发皿中，用水10ml分次洗涤，洗液并入蒸发皿中，蒸干，残渣加0.1mol/L盐酸溶液溶解，转移至25ml量瓶中，加0.1mol/L盐酸溶液至刻度，摇匀，即得。
Take about 0.25g of crude powder of this product, weigh it precisely, put it in 25ml measuring flask, add 0.1mol/L hydrochloric acid solution 20ml, ultrasonic treatment (power 500W, frequency 40kHz) for 30 minutes, let it cool down, add 0.1mol/L hydrochloric acid solution to the scale, shake well. Precision measure 2ml, put in 5ml ampoule, add 2ml hydrochloric acid, 150 ℃ hydrolysis for 1 hour, cooled, transferred to the evaporating dish, washed with 10ml of water in batches, the washings into the evaporating dish, evaporation, residue add 0.1mol/L hydrochloric acid solution dissolved, transferred to a 25ml measuring flask, add 0.1mol/L hydrochloric acid solution to the scale, shaking, that is, obtained.

精密量取上述对照品溶液和供试品溶液各5ml，分别置25ml量瓶中，各加0.1mol/L异硫氰酸苯酯（PITC）的乙腈溶液2.5ml，lmol/L三乙胺的乙腈溶液2.5ml，摇匀，室温放置1小时后，加50%乙腈至刻度，摇匀。取10ml，加正己烷10ml，振摇，放置10分钟，取下层溶液，滤过，取续滤液，即得。
Precisely measure 5ml of each of the above control solution and test solution, respectively, placed in a 25ml measuring flask, add 2.5ml of acetonitrile solution of 0.1mol/L phenyl isothiocyanate (PITC), 2.5ml of acetonitrile solution of lmol/L triethylamine, shaking well, leave for 1 hr at room temperature, add 50% acetonitrile to the scale, shaking well. Take 10ml, add n-hexane 10ml, shaking, placed for 10 minutes, take the lower layer of the solution, filtered, take the renewed filtrate, that is obtained.

测定法 Assay method

分别精密吸取衍生化后的对照品溶液与供试品溶液各5μl，注入液相色谱仪，测定，即得。
Precisely aspirate 5μl each of the derivatised control solution and test solution respectively, inject into the liquid chromatograph and determine, it is obtained.

本品按干燥品计算，含L-羟脯氨酸不得少于8.0%，甘氨酸不得少于18.0%，丙氨酸不得少于7.0%，L-脯氨酸不得少于10.0%。
This product contains not less than 8.0% of L-hydroxyproline, not less than 18.0% of glycine, not less than 7.0% of alanine, and not less than 10.0% of L-proline when calculated on a dry basis.

特征多肽 Signature peptide

照高效液相色谱-质谱法（通则0512和通则0431）测定。
Determined by high performance liquid chromatography-mass spectrometry < 0512,0431>.

色谱、质谱条件与系统适用性试验 Chromatography, mass spectrometry conditions and system suitability tests

以十八烷基硅烷键合硅胶为填充剂（色谱柱内径2.1mm）；以乙腈为流动相A，以0.1%甲酸溶液为流动相B，按下表中的规定进行梯度洗脱，流速为每分钟0.3ml。
Octadecylsilane-bonded silica gel was used as the filler (column inner diameter 2.1 mm); acetonitrile was used as the mobile phase A, and 0.1% formic acid solution as the mobile phase B. Gradient elution was carried out according to the following table at a flow rate of 0.3 ml per minute.

采用三重四极杆质谱检测器，电喷雾离子化（ESI）正离子模式下多反应监测（MRM），监测离子对见下表：
A triple quadrupole mass spectrometry detector was used with electrospray ionisation (ESI) multiple reaction monitoring (MRM) in positive ion mode, and the monitored ion pairs are shown in the table below:

理论板数按驴源多肽A1峰计算应不低于4000。
Theoretical plate counts should be no less than 4000 based on donkey-derived peptide A1 peaks.

对照品溶液的制备 Preparation of reference solution

取驴源多肽A1对照品、驴源多肽A2对照品适量，精密称定，加1%碳酸氢铵溶液分别制成每1ml含2.5μg的混合溶液，即得。
Take the appropriate amount of donkey-derived polypeptide A1 control, donkey-derived polypeptide A2 control, precision weighing, add 1% ammonium bicarbonate solution were made into a mixture of 2.5 μg per 1 ml, i.e., obtained.

供试品溶液的制备 Preparation of test solution

取本品粉末0.1g，精密称定，置50ml量瓶中，加1%碳酸氢铵溶液40ml，超声处理（功率250W，频率40kHz）30分钟，加1%碳酸氢铵溶液稀释至刻度，摇匀。精密量取lml至5ml量瓶中，加胰蛋白酶溶液（取序列分析级胰蛋白酶，加1%碳酸氢铵溶液制成每1ml中含1mg的溶液，临用前新制）lml，加1%碳酸氢铵溶液稀释至刻度，摇匀，37℃恒温酶解12小时，滤过，取续滤液，即得。
Take 0.1g of this product powder, precision weighing, placed in a 50ml measuring flask, add 1% ammonium bicarbonate solution 40ml, ultrasonic treatment (power 250W, frequency 40kHz) for 30 minutes, add 1% ammonium bicarbonate solution to dilute to the scale, shake well. Precision measure lml to 5ml measuring flask, add trypsin solution (take serial analytical grade trypsin, add 1% ammonium bicarbonate solution to make a solution containing 1mg per 1ml, fresh before use) lml, add 1% ammonium bicarbonate solution diluted to the scale, shaking, 37 ℃ constant temperature enzyme solution for 12 hours, filtration, and take the renewed filtrate, that is, obtained.

测定法 Assay method

精密量取对照品溶液1ml、2ml、5ml、10ml、20ml和25ml，分别置50ml量瓶中，加1%碳酸氢铵溶液稀释至刻度，制成标准曲线溶液。分别精密吸取不同浓度的标准曲线溶液与供试品溶液各5μl，注入高效液相色谱-质谱联用仪，以对照品峰面积为纵坐标，对照品浓度为横坐标制备标准曲线。从标准曲线读出供试品溶液中相当于驴源多肽A1和驴源多肽A2的量，计算即得。
Precisely measure 1ml, 2ml, 5ml, 10ml, 20ml and 25ml of the control solution, respectively, in a 50ml measuring flask, add 1% ammonium bicarbonate solution to dilute to the scale, make a standard curve solution. The standard curve solution and test solution of different concentrations were sucked up 5μl each, injected into the high performance liquid chromatography-mass spectrometer, and the standard curve was prepared with the peak area of the control product as the vertical coordinate and the concentration of the control product as the horizontal coordinate. The amount of donkey-derived peptide A1 and donkey-derived peptide A2 in the test solution was read out from the standard curve and calculated.

本品按干燥品计算，含特征多肽以驴源多肽A1（C41H68N12O13）和驴源多肽A2（C51H82N18O18）的总量计应不得少于0.15%。
This product shall contain not less than 0.15% of the total amount of donkey-derived polypeptide A1 (C41H68N12O13) and donkey-derived polypeptide A2 (C51H82N18O18), calculated as a dry product.

饮片 Prepared slices

阿胶 Donkey-hide gelatin

炮制 Processing

捣成碎块。
Crush into small pieces.

性状 Appearance

本品呈不规则块状，大小不一。其余同药材。
The product is irregular in shape and varies in size. The rest is the same as the medicinal material.

检查 Examination

水分 Water

同药材。
Same as the medicinal material.

水不溶物 Insoluble matter

同药材。
Same as the medicinal material.

阿胶珠 Donkey-hide gelatin pill

炮制 Processing

取阿胶，烘软，切成1cm左右的丁，照炒法（通则0213）用蛤粉烫至成珠，内无溏心时，取出，筛去蛤粉，放凉。
Take donkey-hide gelatin, heat and soften it, cut it into pieces about 1cm in size, use the frying method <0213> to cook with clam powder until it forms a pill, remove it when there is no uncooked part inside, sieve off the clam powder, and let it cool.

性状 Appearance

本品呈类球形。表面棕黄色或灰白色，附有白色粉末。体轻，质酥，易碎。断面中空或多孔状，淡黄色至棕色。气微，味微甜。
The product is spherical. The surface is brownish-yellow or grayish-white with white powder attached. It is light in weight, crisp in texture, and fragile. The cross-section is hollow or porous, pale yellow to brown. It has a slight odor and a slightly sweet taste.

检查 Examination

水分 Water

同药材，不得过10.0%。
Same as the medicinal material, not more than 10.0 per cent.

总灰分 Total ash

不得过4.0%（通则2302）。
Not more than 4.0 per cent <2302>.

鉴别 Identification.

同药材。
Same as the medicinal material.

含量测定 Content determination

氨基酸 Amino acids

同药材。
Same as the medicinal material.

性 Property

平。
Neutral.

味 Flavor

甘。
Sweet.

归经 Meridian tropism

归肺、肝、肾经。

功能 Actions

补血滋阴，润燥，止血。
Nourishes blood and nourishes yin, moisturizes dryness, and stops bleeding.

主治 Indications

用于血虚萎黄，眩晕心悸，肌痿无力，心烦不眠，虚风内动，肺燥咳嗽，劳嗽咯血，吐血尿血，便血崩漏，妊娠胎漏。
Used for blood deficiency and withered yellow, dizziness and palpitations, muscular atrophy and weakness, restlessness and insomnia, deficiency wind stirring internally, lung dryness cough, cough with blood due to exertion, vomiting blood and hematuria, bleeding and collapse, and threatened abortion during pregnancy.

用量 Dosage

3～9g。
3-9g.

用法 Administration

烊化兑服。
Closed and blended.

贮藏 Storage

密闭。
Store in a sealed container.

阿胶

文本参考：《中国药典（2015年版）》
Text reference: Chinese Pharmacopoeia (2015 Edition)

概述 Overview

本品为马科动物驴Equus asinm L.的干燥皮或鲜皮经煎煮、浓缩制成的固体胶。
Donkey-hide Glue is the solid glue prepared from the dried or fresh skin of Equus asinus Linnaeus (Fam. Equidae) by decoction and concentration.

制法 Procedure

将驴皮浸泡去毛，切块洗净，分次水煎，滤过，合并滤液，浓缩（可分别加入适量的黄酒、冰糖及豆油）至稠膏状，冷凝，切块，晾干，即得。
Soak the donkey-hide, remove the hairs, cut into small pieces, rinse again, decoct with water several times, filter and combine the filtrates. Concentrate the glutinous filtrate ( or add a quantity of yellow rice wine, crystal sugar, soya-bean oil, respectively) to thick glue, allow to cool and congeal, cut into pieces, and dry in the air.

性状 Description

本品呈长方形块、方形块或丁状。棕色至黑褐色，有光泽。质硬而脆，断面光亮，碎片对光照视呈棕色半透明状。气微，味微甘。
Rectangular, square piece or small piece, brown to dark-brown, lustrous. Texture hard and fragile, fracture lustrous, fragment brown and translucent when looking against the light. Odour, slight； taste, slightly sweet.

鉴别 Identification

取本品粉末0.1g，加1%碳酸氢铵溶液50ml，超声处理30分钟，用微孔滤膜滤过，取续滤液l00μl，置微量进样瓶中，加胰蛋白酶溶液10μl（取序列分析用胰蛋白酶，加1%碳酸氢铵溶液制成每1ml中含1mg的溶液，临用时配制），摇匀，37℃恒温酶解12小时，作为供试品溶液。另取阿胶对照药材0.1g，同法制成对照药材溶液。照高效液相色谱-质谱法（通则0512和通则0431）试验，以十八烷基硅烷键合硅胶为填充剂（色谱柱内径为2.1mm）；以乙腈为流动相A，以0.1%甲酸溶液为流动相B，按下表中的规定进行梯度洗脱；流速为每分钟0.3ml。采用质谱检测器，电喷雾正离子模式（ESI+），进行多反应监测（MRM），选择质荷比（m/z） 539.8（双电荷）→612.4和m/z 539.8（双电荷）→923.8作为检测离子对。取阿胶对照药材溶液，进样5μl，按上述检测离子对测定的MRM色谱峰的信噪比均应大于3：1。
To 0.1 g of the powder, add 50 ml of 1% solution of ammonium bicarbonate, ultrasonicate for 30 minutes, filter with millipore filter. Transfer 100 μl of the successive filtrate into a trace sample bottle, add 10 μl of trypsin solution ( dissolve trypsin for sequence analysis in 1% solution of ammonium bicarbonate to produce a solution containing 1 mg per ml, prepare when use) , mix well, hydrolyze by enzyme at 37℃ for 12 hours, use the hydrolysate as the test solution. Prepare a solution of 0.1 g of Asini Corii Colla reference drug in the same manner as the reference drug solution. Carry out the method for high performance liquid chromatography-mass spectrometry 〈 0512 and 0431〉, use octadecylsilane bonded silica gel as the stationary phase (2.1 mm in inner diameter) , and use acetonitrile as the mobile phase A, 0.1% solution of formic acid as mobile phase B, elute in gradient at 0.3 ml per minute as the following:

As detector a mass spectrometer set in positive electrospray ionization ( ESI＋ ) interface, using multiple reactions monitoring (MRM) mode. Monitor the ion pairs at m/z 539.8 (double charged) →612.4 and m/z 539. 8 (double charged) →923.8. Inject 5 μl of each of the reference drug solution and the test solution respectively to the column and determine. The signal to noise ratio (SNR) of the peaks in the chromatogram obtained with the reference solution should be greater than 3 : 1. The peaks in the chromatogram obtained with the test solution correspond in retention time to the peaks in the chromatogram obtained with the reference drug solution.

检查 Examination

水分 Water

取本品1g，精密称定，加水2ml，加热溶解后，置水浴上蒸干，使厚度不超过2mm，照水分测定法（通则0832第二法）测定，不得过15.0%。
Heat to dissolve 1 g, accurately weighed, in 2 ml of water, and evaporate to dryness on a water bath. Keep the thickness not over than 2 mm. Carry out the method for the determination of water 〈 0832 , method 2 〉, not more than 15.0 per cent.

重金属及有害元素 Heavy metals and harmful elements

照铅、镉、砷、汞、铜测定法（通则2321原子吸收分光光度法或电感耦合等离子体质谱法）测定， 铅不得过5mg/kg；镉不得过0.3mg/kg；砷不得过2mg/kg，汞不得过0.2mg/kg，铜不得过20mg/kg。
Carry out the method for determination of lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg) and copper (Cu)〈2321, atomic absorption spectrophotometry or inductively-coupled plasma mass spectrometry), not more than 5 mg/kg of Pb; not more than 0.3 mg/kg of Cd； not more than 2 mg/kg of As； not more than 0.2 mg/kg of Hg； not more than 20 mg/ kg of Cu.

水不溶物 Insoluble matter in water

取本品1.0g，精密称定，加水5ml，加热使溶解，转移至巳恒重10ml具塞离心管中，用温水5ml分3次冼涤，洗液并入离心管中，摇匀。置40℃水浴保温15分钟，离心（转速为每分钟2000转）10分钟，去除管壁浮油，倾去上清液，沿管壁加入温水至刻度，离心，如法清洗3次，倾去上清液，离心管在105℃加热2小时，取出，置干燥器中冷却30分钟，精密称定，计算，即得。
Weigh accurately 1.0 g of the powder in a flask, add 5 ml of water and heat to dissolve. Transfer to a 10 ml stoppered centrifuge tube previously dried to constant weight. Wash the flask 3 times with 5 ml of warm water, combine the washings to the centrifuge tube and mix well. Keep warm on a water bath at 40℃ for 15 minutes, centrifuge ( 2000 rotations per minute) for 10 minutes, discard the oil slick on tube wall and supernatant. Add warm water to volume along the tube wall, centrifuge, wash 3 times in the same manner and discard the supernatant. Heat the centrifuge tube at 105℃ for 2 hours, take out, cool in a desiccator for 30 minutes, weigh accurately and calculate, not more than 2.0 per cent.

其他 Other requirements

应符合胶剂项下有关的各项规定（通则0184）。
Complies with the general requirements for glues 〈 0184 〉.

含量测定 Assay

照高效液相色谱法（通则0512）测定。
Carry out the method for high performance liquid chromatography 〈0512).

饮片 Prepared slices

阿胶 Asini Corii Colla

炮制 Processing

捣成碎块。
Pound into pieces.

阿胶珠 Asini Corii Colla (beaded)

取阿胶，烘软，切成1cm左右的丁，照烫法 （通则0213）用蛤粉烫至成珠，内无溏心时，取出，筛去蛤粉，放凉。
Soften by heating, cut into small squares (about 1 cm long), then stir-bake to beads as described under the method for stir-baking with powdered clam-shell〈 0213〉until the inner not runny, take out, remove the powdered clam-shell by sifting, and allow to cool.

检查 Examination

水分 Water

同药材，不得过10.0%，
Same as the crude drug, not more than 10.0%.

总灰分 Total ash

同药材，不得过4.0%。
Same as the crude drug, not more than 4.0%.

鉴别 Identification

同药材。
Same as the crude drug.

含量测定 Assay

同药材。
Same as the crude drug.

性味与归经 Property and Flavor

甘，平。归肺、肝、肾经。
Neutral ； sweet. Meridian tropism Lung, liver and kidney meridians.

功能与主治 Actions

补血滋阴，润燥，止血。用于血虚萎黄，眩晕心悸，肌痿无力，心烦不眠，虚风内动，肺燥咳嗽，劳嗽咯血，吐血尿血，便血崩漏，妊娠胎漏。
To nourish blood, replenish yin, moisten dryness, and stanch bleeding. Indicated for blood deficiency with sallow complexion, dizziness, palpitations, weak muscle, lack of strength, insomnia caused by vexation, internal stirring of defiency wind, cough caused by lung dryness, cough in consumptive disease, hemoptysis, hematemesis and hematuria, bloody stool, memstrnal flooding and spotting, and vaginal bleeding during pregnancy.

用法与用量 Administration and dosage

3～9g。烊化兑服。
3-9 g, taken after dissolving in boiling decoction.

贮藏 Storage

密闭。
Preserve in tightly closed container.