This product is a medicinal material commonly used by the Tibetan people. It is the dried whole plant of Lagotis brevituba Maxim., a plant from the Scrophulariaceae family. It is harvested during the flowering seasons of summer and autumn, impurities are removed, it is cleaned, and then dried in the shade.
NMM ID | nmm-01ju |
Systematic Name | Lagotis brevituba Herb |
Systematic Chinese Name | 短筒兔耳草全草（duǎn tǒng tù ěr cǎo quán cǎo） |
Generic Name | Hong-lian |
Generic Chinese Name | 洪连（hóng lián） |
NMM Type | plant |
Species Origins | Lagotis brevituba | 短筒兔耳草 |
Medicinal Parts | herb | 全草 |
Special Descriptions | |
Processing Methods | |
Systematic Name Explanation | This product is a medicinal material commonly used by the Tibetan people. It is the dried whole plant of Lagotis brevituba Maxim., a plant from the Scrophulariaceae family. It is harvested during the flowering seasons of summer and autumn, impurities are removed, it is cleaned, and then dried in the shade. |
Generic Name Explanation | NMMGN follows the Chinese name of the relevant Chinese medicinal materials in the Chinese Pharmacopoeia: 2020 edition: Volume I. |
Parent NMM | |
Child NMMs | |
Creators | |
Reviewers |
洪连
English text reference: *Chinese Pharmacopoeia (2020 Edition) *
Overview
Lagotidis Herb is the dried aerial part of Lagotis brevituba Maxim. (Fam. Scrophulariaceae). The drug is collected in summer and autumn at flowering, removed from impurities, washed, and dried in the shade.
Description
The drug is 5-15 cm long. Rhizome cylindrical, slightly curved, internodes close together, resembling silkworm; surface grayish-brown or light purplish-brown; texture brittle, easily broken, fracture brownish or grayish-yellow, with 3-4 white dot-like vascular bundles arranged in a ring. Roots slender, cylindrical, twisted, surface light yellowish-brown or grayish-brown, with longitudinal wrinkles. Radical leaves with long petioles; leaf blades crumpled and broken, when whole, circular or ovate, blunt at apex, margin with rounded teeth, base broadly cuneate. Spike-like inflorescence terminal. Fruit elongate-ovoid, blackish-brown. Odour, slight; taste, slightly bitter.
Identification
（1）The powder is reddish-brown. Numerous starch grains, single grains are round, with a diameter of 3-7 μm, occasionally helmet-shaped, with a dot-like hilum; compound grains consist of 2-3 (6) component grains. Thin-walled cells are round or round-like, containing light brown round-like nuclear substances. Epidermal cells of the lower surface of the leaf have slightly curved periclinal walls, stomata are anomocytic and anisocytic. Vessels are mostly reticulate and spiral.
（2）To 0.5 g of the powder add 10 ml of methanol, treat with ultrasound for 15 minutes, filter, and use the filtrate as the test solution. Prepare separately a solution of the reference substances, arctiin and verbascoside, in methanol to contain 1 mg per ml as the Reference solution. Carry out the method for thin layer chromatography <0502>, using polyamide film as the coating substance and a mixture of methanol-acetic acid-water (2: 1: 7) as the mobile phase. Apply separately to the plate 2 μl of each of the above three solutions. After developing and removal of the plate, dry in air. Examine under ultraviolet light at 365 nm. The fluorescent spot in the chromatogram obtained with the test solution corresponds in position and colour to the spot in the chromatogram obtained with the Reference solution.
Examination
Water
Not more than 8.0 per cent <0832, method 2>.
Total ash
Not more than 15.0 per cent <2302>.
Acid-insoluble ash
Not more than 10.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble Extractives <2201, the cold maceration method>, using ethanol as the solvent, not less than 8.0 per cent.
Assay
Carry out the method for high performance liquid chromatography <0512>.
Chromatographic conditions and system suitability test
Use octadecylsilane bonded silica gel as the filler; use acetonitrile-methanol-1% acetic acid solution (10: 15: 75) as the mobile phase; detection wavelength is 334 nm. The theoretical plate number calculated from the peak of arctiin should not be less than 4000.
Preparation of reference solution
Take an appropriate amount of arctiin reference substance, accurately weigh, place it in a brown volumetric flask, add the mobile phase to make a solution containing 0.25 mg per ml, and mix well.
Preparation of test solution
Take about 0.5 g of the powder (passed through a No. 4 sieve) of the test substance, accurately weigh, place it in a 50 ml brown volumetric flask, accurately add 25 ml of the mobile phase, weigh, soak for 30 minutes, treat with ultrasound (power 230 W, frequency 35 kHz) for 15 minutes, cool, weigh again, make up for the lost weight with the mobile phase, shake well, centrifuge, let stand, take the supernatant and place it in a brown bottle, and obtain the test solution.
Assay method
Accurately draw 10-20 μl of the reference solution and the test solution, respectively, inject into the liquid chromatograph, and determine.
Calculated on the dried basis, the content of arctiin (C33H46O20) should not be less than 0.80%.
Property
Cold.
Flavor
Bitter and sweet.
Meridian tropism
Lung, heart, and liver meridians.
功能 ｜ Actions
To clear heat, detoxify, promote diuresis, soothe the liver, promote blood circulation, and regulate menstruation.
Indications
Used for fever and thirst, lung heat cough, headache and dizziness, damp-heat jaundice, irregular menstruation, and poisoning by drugs and food.
Dosage
1-6 g.
用法 ｜ Administration
None.
Storage
Preserve in a well-ventilated and dry place.
洪连
Text reference: Chinese Pharmacopoeia (2015 Edition)
Overview
Shorttube Lagotis Herb is the dried herb of Lagotis brevituba Maxim. (Fam. Scrophulariaceae), commonly used by the Tibetan nationality. The drug is collected at flowering season in summer and autumn, removed from foreign matter, washed clean, and dried in the shade.
Description
5-15 cm long. Rhizomes cylindrical, slightly curved, internodes very short like a silkworm; externally greyish-brown or pale purplish-brown; texture fragile, easily broken, fracture brown or greyish-yellow, 3-4 white dotted vascular bundles arranged in a ring. Roots slender, cylindrical twisted, externally pale yellowish-brown or greyish-brown, with longitudinal wrinkles. Leaves basal, long petioled; lamina mostly rolled and broken, when whole, rounded or ovoid, apex obtuse, margin rounded-serrate, base broadly cuneate. Spike terminal. Fruits oblong, blackish-brown. Odour, slight; taste, slightly bitter.
Identification
（2）取本品粉末0.5g，加甲醇10ml，超声处理15分钟，滤过，滤液作为供试品溶液。另取松果菊苷对照品、毛蕊花糖苷对照品，加甲醇分别制成每1ml含1mg的溶液，作为对照品溶液。照薄层色谱法（通则0502）试验，吸取上述三种溶液各2μl，分别点于同一聚酰胺薄层板上，以甲醇-醋酸-水（2：1：7）为展开剂，展开，取出，晾干，置紫外光灯（365nm）下检视。供试品色谱中在与对照品色谱相应的位置上，显相同颜色的荧光斑点。
Examination
Water
Not more than 8.0 per cent <0832, method 2>.
Total ash
Not more than 15.0 per cent <2302>.
Acid-insoluble ash
Not more than 10.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble extractives <2201, the cold maceration method>, using ethanol as the solvent, not less than 8.0 per cent.
Assay
Carry out the method for high-performance liquid chromatography <0512>.
Storage
Preserve in a ventilated and dry place.
This product is a medicinal material commonly used by the Tibetan people. It is the dried whole plant of Lagotis brevituba Maxim., a plant from the Scrophulariaceae family. It is harvested during the flowering seasons of summer and autumn, impurities are removed, it is cleaned, and then dried in the shade.