This product is the dried root bark of the plant Periploca sepium Bge., a member of the Apocynaceae family. It is harvested and the root bark is peeled off in both spring and autumn seasons, then dried in the sun.
NMM ID | nmm-01il |
Systematic Name | Periploca sepium Bark-root |
Systematic Chinese Name | 杠柳根皮（gāng liǔ gēn pí） |
Generic Name | Xiang-jia-pi |
Generic Chinese Name | 香加皮（xiāng jiā pí） |
NMM Type | plant |
Species Origins | Periploca sepium | 杠柳 |
Medicinal Parts | bark root | 根皮 |
Special Descriptions | |
Processing Methods | |
Systematic Name Explanation | This product is the dried root bark of the plant Periploca sepium Bge., a member of the Apocynaceae family. It is harvested and the root bark is peeled off in both spring and autumn seasons, then dried in the sun. |
Generic Name Explanation | NMMGN follows the Chinese name of the relevant Chinese medicinal materials in the Chinese Pharmacopoeia: 2020 edition: Volume I. |
Parent NMM | |
Child NMMs | |
Creators | |
Reviewers |
香加皮
English text reference: Chinese Pharmacopoeia (2020 Edition)
Overview
Periploca Bark is the dried root bark of Periploca sepium Bge. (Fam. Asclepiadaceae). The drug is collected in spring and autumn, the root bark is peeled off, and dried in the shade.
Description
The bark is cylindrical or trough-shaped, occasionally irregularly blocky, 3-10 cm long, 1-2 cm in diameter, and 0.2-0.4 cm thick. The outer surface is grayish-brown or yellowish-brown, with loose cork often in scales that are easily peeled off. The inner surface is pale yellow or pale yellowish-brown, relatively smooth, with fine longitudinal striations. The bark is light, brittle, easily broken, with an uneven fracture surface, and yellowish-white. It has a characteristic aroma and a bitter taste.
Identification
(1) The powder of this product is light brown. Calcium oxalate square crystals 9-20 μm in diameter. stone cells oblong or polygonal-like, 24-70 μm in diameter. milk tubes containing colourless oil droplet-like particles. Cork cells are brownish yellow, polygonal. Starch granules are numerous, single granules are oblong or oblong, 3～l1μm in diameter; compound granules are composed of 2～6 grains.
(2) Take 10g of this product powder, placed in 250ml flask, add 150ml of water, heating distillation, distillate with a specific aroma, collect 10ml of distillate, divided into two test tubes, a tube with 1% ferric chloride solution 1 drop, that is, a reddish-brown colour; the other tube with a small amount of hydrazine sulphate saturated solution 5ml and sodium acetate crystals, a little heated, cooled to produce a yellowish-green precipitate, and placed in ultraviolet light (365nm) under the observation, showed strong yellow fluorescence.
(3) Take 1g of this product powder, add 10ml of ethanol, heat and reflux for 1 hour, filtration, filtrate in a 25ml measuring flask, add ethanol to the scale, shaking well, a precise amount of 1ml, placed in a 20ml measuring flask, add ethanol to the scale, shaking well, according to the UV-visible spectrophotometric method (General 0401) to determine the wavelength of 278nm has the maximum absorption.
(4) Take 2g of this product powder, add 30ml of methanol, heating reflux for 1 hour, filtration, filtrate evaporation, residue add 2ml of methanol to dissolve, as a test solution. Take 4-methoxysalicylaldehyde control product, add methanol to make a solution containing lmg per 1ml, as a control solution. According to the thin layer chromatography (General rule 0502) test, absorb the above two solutions of 2μl, respectively, point on the same silica gel G thin layer plate, with petroleum ether (60 ~ 90 ℃) - ethyl acetate - glacial acetic acid (20:3:0.5) as the unfolding agent, unfold, remove, dry, spray with dinitrophenylhydrazine test solution. In the chromatogram of the test article, spots of the same colour are shown in the corresponding positions with the chromatogram of the control article.
Examination
Water
Not more than 13.0 per cent <0832,method 2>.
Total ash
Not more than 10.0 per cent <2302>.
Acid-insoluble ash
Not more than 4.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble Extractives <2201,the hot maceration method>, using diluted ethanol as the solvent, not less than 20.0 per cent.
Assay
Carry out the method for high performance liquid chromatography <0512>.
Chromatographic conditions and system suitability test
Use octadecylsilane bonded silica gel as the stationary phase; use methanol-water-acetic acid (70:30:2) as the mobile phase; detect at a wavelength of 278 nm. The theoretical plate number calculated based on the peak of 4-methoxysalicylaldehyde should not be less than 1000.
Preparation of internal standard solution
Take an appropriate amount of butylparaben, accurately weigh, and dissolve in 60% methanol to obtain a solution containing 6 mg per ml.
Assay method
Take an appropriate amount of 4-methoxysalicylaldehyde reference substance, accurately weigh, place it in a brown volumetric flask, and dissolve it in 60% methanol to obtain a solution containing 1 mg per ml. Accurately measure 4 ml of this solution and 2 ml of the internal standard solution, place them in a 25 ml volumetric flask, add 60% methanol to the mark, shake well, take 20 μl, inject it into the liquid chromatograph, and record the chromatogram. Take about 0.25-0.5 g of the coarse powder of the drug, dry it at 60°C for 4 hours, accurately weigh it, place it in a 50 ml flask, add 15 ml of 60% methanol, heat under reflux for 1.5 hours, filter, collect the filtrate in a 25 ml volumetric flask, wash the container with a small amount of 60% methanol, and filter the washings into the same flask. Accurately add 2 ml of the internal standard solution, add 60% methanol to the mark, shake well, filter, and take the subsequent filtrate as the test solution. Take 20 μl and inject it into the liquid chromatograph. Calculate the content based on the peak area using the internal standard method.
When dried at 60°C for 4 hours, the content of 4-methoxysalicylaldehyde (C8H8O3) should not be less than 0.20%.
Prepared slices
Periploca Bark
Processing
Eliminate Foreign matter, wash, soften briefly, cut into thick slices, and dry in the sun.
Description
This product comes in thick irregular sheets. The outer surface is greyish brown or yellowish brown, and the embolus is often scaly. The inner surface is yellowish or yellowish brown with fine longitudinal lines. The cut surface is yellowish white. It has special aroma and bitter taste.
Identification
Same as the crude drug.
Examination
Same as the crude drug.
Assay
Same as the crude drug.
Property
Warm.
Toxicity
Toxic.
Flavor
Pungent and bitter.
Meridian tropism
Liver, kidney, and heart meridians.
Actions
To promote diuresis, reduce swelling, dispel wind and dampness, and strengthen tendons and bones.
Indications
Used for lower limb edema, palpitations and shortness of breath, wind-cold-damp arthralgia, and lumbago and knee weakness.
Dosage
3-6 g.
Administration
None.
Precautions
Do not take excessive doses.
Storage
Preserve in a cool and dry place.
香加皮
Text reference: Chinese Pharmacopoeia (2015 Edition)
Overview
Chinese Silkvine Root-bark is the dried root bark of Periploca sepium Bge. (Fam. Asclepiadaceae ). The root is collected in spring and autumn, the root bark is stripped off, and dried in the sun.
Description
Quilled or channelled, a few pieced irregularly, 3-10 cm long, 1-2 cm in diameter, 2-4 mm thick. Outer surface greyish-brown or yellowish-brown, cork soft and loose, often scaly, easily exfoliated; inner surface pale yellow or pale yellowish-brown, relatively smooth, with fine longitudinal striations. Texture light and fragile, easily broken, fracture uneven, yellowish-white. Odour, characteristic and aromatic; taste, bitter.
Identification
（2）取本品粉末10g，置250ml烧瓶中，加水150ml，加热蒸馏，馏出液具特异香气，收集馏出液10ml，分置二支试管中，一管中加1%三氯化铁溶液1滴，即显红棕色；另一管中加硫酸肼饱和溶液5ml与醋酸钠结晶少量，稍加热，放冷，生成淡黄绿色沉淀，置紫外光灯（365nm）下观察，显强烈的黄色荧光。
Examination
Water
Not more than 13.0 per cent <0832, method 2>.
Total ash
Not more than 10.0 per cent <2302>.
Acid-insoluble ash
Not more than 4.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble Extractives <2201, the hot extraction method>, using dilute ethanol as the solvent, not less than 20.0 per cent.
Prepared slices
Chinese Silkvine Root-bark
Processing
Eliminate Foreign matter, wash clean, soften thoroughly, cut into thick slices, and dry in the sun.
Property
Warm.
Flavor
Pungent and bitter.
Meridian tropism
Liver, kidney and heart meridians.
Actions
To promote urination, alleviate edema, dispel wind-dampness, and strengthen sinew and bone.
Indications
Edema in the lower limbs, palpitation, shortness of breath, wind cold dampness disorder, and soreness and weakness in the lower back and knees.
Dosage
3-6 g.
Precautions and Warnings
Avoid overdosage.
Storage
Preserve in a cool and dry place.
This product is the dried root bark of the plant Periploca sepium Bge., a member of the Apocynaceae family. It is harvested and the root bark is peeled off in both spring and autumn seasons, then dried in the sun.