This product is the dried whole plant of Lysimachia christinae Hance, a plant from the Primulaceae family. It is harvested in summer and autumn, impurities are removed, and then it is dried in the sun.
NMM ID | nmm-01aa |
Systematic Name | Lysimachia christinae Herb |
Systematic Chinese Name | 过路黄全草（guò lù huáng quán cǎo） |
Generic Name | Jin-qian-cao |
Generic Chinese Name | 金钱草（jīn qián cǎo） |
NMM Type | plant |
Species Origins | Lysimachia christinae | 过路黄 |
Medicinal Parts | herb | 全草 |
Special Descriptions | |
Processing Methods | |
Systematic Name Explanation | This product is the dried whole plant of Lysimachia christinae Hance, a plant from the Primulaceae family. It is harvested in summer and autumn, impurities are removed, and then it is dried in the sun. |
Generic Name Explanation | NMMGN follows the Chinese name of the relevant Chinese medicinal materials in the Chinese Pharmacopoeia: 2020 edition: Volume I. |
Parent NMM | |
Child NMMs | |
Creators | |
Reviewers |
金钱草
English text reference: *Chinese Pharmacopoeia (2020 Edition) *
Overview
Lysimachia Herb is the dried aerial part of Lysimachia christinae Hance (Fam. Primulaceae). The drug is collected in summer and autumn, removed from impurities, and dried.
Description
The drug is often tangled into a mass, hairless or sparsely pubescent. Stems twisted, surface brown or dark reddish-brown, with longitudinal ridges, sometimes with adventitious roots at lower nodes, solid in cross-section. Leaves opposite, mostly wrinkled and crumpled, when flattened, broadly ovate or cordate, 1-4 cm long, 1-5 cm wide, slightly concave at base, entire at margin; upper surface grayish-green or brownish-brown, lower surface lighter, main veins distinctly raised, when soaked in water, black or brown stripes visible by transmitted light; petiole 1-4 cm long. Some with flowers, yellow, solitary in leaf axils, with long pedicels. Capsule globose. Odour, faint; taste, insipid.
Identification
（1）Transverse section of stem: Epidermal cells covered with a cuticle, sometimes glandular hairs visible, head cells single, stalk cells 1-2. Cork layer wide[1], some cells containing reddish-brown secretions; secretory ducts scattered, surrounded by 5-10 secretory cells, containing reddish-brown block secretions; endodermis distinct. Medullary sheath fibres arranged in interrupted rings, walls slightly lignified. Phloem narrow. Xylem arranged in rings. Pith often hollow. Thin-walled cells containing starch grains.
Leaf surface: Glandular hairs reddish-brown, head cells single, nearly circular, 25 μm in diameter, stalk cells single. Secretory ducts scattered in leaf parenchyma, 45 μm in diameter, containing reddish-brown secretions. Non-glandular hairs visible on stems and leaf surfaces, 1-17 cells, straight or curved, some cells constricted, 59-1070 μm long, 13-53 μm in diameter at base, surface with fine striations, cell cavity containing yellowish-brown substance.
（2）To 1 g of the powder add 50 ml of 80% methanol, heat under reflux for 1 hour, cool, filter, evaporate the filtrate to dryness, dissolve the residue in 10 ml of water, extract with two 10-ml portions of ether, discard the ether layer, add 10 ml of dilute hydrochloric acid to the aqueous layer, heat in a water bath for 1 hour, remove, cool rapidly, extract with two 20-ml portions of ethyl acetate, combine the ethyl acetate layers, wash with 30 ml of water, discard the aqueous layer, evaporate the ethyl acetate layer to dryness, dissolve the residue in 1 ml of methanol as the test solution. Prepare a solution containing 0.5 mg of quercetin CRS and a solution containing 0.5 mg of kaempferol CRS in methanol as the Reference solution. Carry out the method for thin layer chromatography <0502>, using silica gel G as the coating substance and a mixture of toluene-ethyl acetate-formic acid (10: 8: 1) as the mobile phase. Apply separately to the plate 5 μl of the test solution and 2 μl of each of the Reference solutions. After developing and removal of the plate, dry in air. Spray with a 3% solution of aluminium chloride in ethanol, heat at 105 °C for a few minutes, examine under ultraviolet light at 365 nm. The fluorescent spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the Reference solutions.
Examination
Impurities
Not more than 8.0 per cent <2301>.
Water
Not more than 13.0 per cent <0832, method 2>.
Total ash
Not more than 13.0 per cent <2302>.
Acid-insoluble ash
Not more than 5.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble Extractives <2201, the hot maceration method>, using 75% ethanol as the solvent, not less than 8.0 per cent.
Assay
Carry out the method for high performance liquid chromatography <0512>.
Chromatographic conditions and system suitability test
Use octadecylsilane bonded silica gel as the filler; use methanol-0.4% phosphoric acid solution (50: 50) as the mobile phase; detection wavelength is 360 nm. The theoretical plate number calculated from the quercetin peak should not be less than 2500.
Preparation of reference solution
Accurately weigh an appropriate amount of quercetin CRS and kaempferol CRS, add 80% methanol to make a solution containing 4 μg of quercetin and 20 μg of kaempferol per ml.
Preparation of test solution
Accurately weigh about 1.5 g of the powder (passed through a No. 3 sieve) of the drug, place it in a stoppered conical flask, accurately add 50 ml of 80% methanol, stopper tightly, weigh, heat under reflux for 1 hour, cool, weigh again, make up the loss in weight with 80% methanol, shake well, filter. Accurately measure 25 ml of the filtrate, accurately add 5 ml of hydrochloric acid, heat in a water bath at 90°C for 1 hour, remove, cool rapidly, transfer to a 50 ml volumetric flask, dilute with 80% methanol to the mark, shake well, filter, take the filtrate, and set aside.
Assay method
Accurately draw 10 μl of each of the reference solution and the test solution, inject into the liquid chromatograph, and determine.
Calculated on the dried basis, the total content of quercetin (C15H10O7) and kaempferol (C15H10O6) should not be less than 0.10%.
Prepared slices
Lysimachia Herb
Processing
Eliminate Foreign matter, rinse with Water, cut into sections, and dry.
Description
In irregular sections. Stems brown or dark brown, striated longitudinally, fracture solid. Leaves opposite, when whole, broadly ovate or cordate; the upper surface greyish-green or dark brown, the lower surface pale in colour, midrib distinctly prominent, the black or brown stripes visible against the light after soaking in water. Occasionally flowers, yellow, solitary vein. Odour, slight; taste, weak.
Identification
As required for the crude drug.
Examination
Water
As required for the crude drug.
Total ash
As required for the crude drug.
Acid-insoluble ash
As required for the crude drug.
Extractives
As required for the crude drug.
Assay
As required for the crude drug.
Property
Slightly cold.
Flavor
Sweet and salty.
Meridian tropism
Liver, gallbladder, kidney, and bladder meridians.
Actions
To eliminate dampness and relieve jaundice, promote diuresis and relieve stranguria, detoxify and reduce swelling.
Indications
Used for damp-heat jaundice, distension and pain in the hypochondrium, urinary calculi, hot stranguria, painful urination, carbuncles and furuncles, snake and insect bites.
Dosage
15-60 g.
Administration
None.
Storage
Preserve in a dry place.
金钱草
Text reference: Chinese Pharmacopoeia (2015 Edition)
Overview
Christina Loosestrife is the dried herb of Lysimachia christinae Hance (Fam. Primulaceae). The drug is collected in summer and autumn, removed from foreign matter, and dried in the sun.
Description
Frequently twisted into masses, glabrous or sparsely pubescent. Stems twisted, externally brown or dark brownish-red, striated longitudinally, stem nodes of the lower part sometimes with rootlets, fracture solid. Leaves opposite, mostly crumpled, when whole, broadly ovate or cordate, 1-4 cm long, 1-5 cm wide, base slightly concave, margin entire; the upper surface greyish-green or dark brown, the lower surface pale in colour, midrib distinctly prominent, after soaking in water, the black or brown stripes visible under the light; petioles 1-4 cm long. Some with flowers, yellow, solitary and axillary, long-petioled. Capsules globose. Odour, slight; taste, weak.
Identification
叶表面观：腺毛红棕色，头部单细胞，类圆形，直径25µm，柄单细胞。分泌道散在于叶肉组织内，直径45µm，含红棕色分泌物。被疏毛者茎、叶表面可见非腺毛，1～17细胞，平直或弯曲，有的细胞呈缢缩状，长59～1070µm，基部直径13～53µm，表面可见细条纹，胞腔内含黄棕色物。
Examination
Foreign matter
Not more than 8 per cent <2301>.
Water
Not more than 13.0 per cent <0832, method 2>.
Total ash
Not more than 13.0 per cent <2302>.
Acid-insoluble ash
Not more than 5.0 per cent <2302>.
Extractives
Carry out the method for determination of ethanol-soluble extractives <2201, the hot extraction method>, using 75% ethanol as the solvent, not less than 8.0 per cent.
Assay
Carry out the method for high performance liquid chromatography <0512>.
以十八烷基硅烷键合硅胶为填充剂；以甲醇-0.4%磷酸溶液（50：50）为流动相；检测波长为360nm。理论板数按槲皮素峰计算应不低于2500。
Property
Mild cold; sweet and salty.
Flavor
Weak cold.
Meridian tropism
Liver, gallbladder, kidney, and bladder meridians.
Actions
To drain dampness, abate jaundice, disinhibit urine, relieve stranguria, remove toxin, and relieve swelling.
Indications
Dampness-heat jaundice, gallbladder distention, hypochondriac pain, stone strangury, heat strangury, difficult and painful urination, swelling abscess, deep-rooted boil, sore, and bites of insect, worm, or snake.
Dosage
15-60 g.
Administration
No special requirements.
Storage
Preserve in a dry place.
This product is the dried whole plant of Lysimachia christinae Hance, a plant from the Primulaceae family. It is harvested in summer and autumn, impurities are removed, and then it is dried in the sun.